PP-064 A tenofovir therapy HBV mathematical model for HBeAg negative and positive patient
نویسندگان
چکیده
منابع مشابه
Efficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic Hepatitis B Patients with High HBV DNA.
OBJECTIVES To compare entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effects in chronic hepatitis B (CHB) patients with high HBV DNA. METHOD 96 patients treated initially with tenofovir (TDF group) or entecavir (ETV group) were included in this retrospective study. The following parameters were assessed: HBeAg and hepatitis B e antibody (anti-HBe) status, serum alanine aminotransfera...
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BACKGROUND Prolonged adefovir therapy exposes to the emergence of adefovir resistant hepatitis B virus mutants. Initial reports of the rtN236T mutation showed preserved sensitivity to lamivudine; however, complex mutations are emerging with reduced susceptibility to lamivudine. CASE PRESENTATION After 2 years of therapy, a cirrhotic patient developed the rtN236T and rtA181T adefovir resistant...
متن کاملCorrelations of HBV Genotypes, Mutations Affecting HBeAg Expression and HBeAg/ anti-HBe Status in HBV Carriers
This study was carried out to determine the effects of hepatitis B virus genotypes, core promoter mutations (A1762G1764-->T1762A1764) as well as precore stop codon mutations (TGG-->TAG) on HBeAg expression and HBeAg/ anti-HBe status. Study was also performed on the effects of codon 15 variants (C1858/ T1858) on the predisposition of precore stop codon mutations (TGG-->TAG). A total of 77 sera s...
متن کاملHBV DNA suppression and HBsAg clearance in HBeAg negative chronic hepatitis B patients on lamivudine therapy for over 5 years.
BACKGROUND & AIMS In long-term responder patients, it is unclear whether lamivudine (LAM) monotherapy should be continued or switched to a high-genetic-barrier analogue. This study aims at assessing LAM efficacy over a 5-year period and the residual risk of drug resistance. The rate of HBsAg clearance and LAM long-term safety profile were also evaluated. METHODS One hundred and ninety-one pat...
متن کاملA Mathematical Model for Operating Room Scheduling Considering Limitations on Human Resources Access and Patient Prioritization
Operating room scheduling is an important task in healthcare sector. This study proposes a Mixed Integer Nonlinear Programming (MINLP) mathematical model for the scheduling of the operating rooms. In the presented model, apart from scheduling the patients’ surgery process, shifting of the medical staff is also carried out. The innovation considered in the proposed model is aimed at prioritizing...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2009
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(09)60458-6